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Case Reports
February 1939


Am J Dis Child. 1939;57(2):349-359. doi:10.1001/archpedi.1939.01990020107011

For a quarter of a century it has been recognized that a condition of abnormal hemopoiesis exists in newborn infants who exhibit general edema or hydrops foetalis. More recently the same blood picture has been described in fatal jaundice of the newborn and in congenital anemia. Excellent reviews of the literature on erythroblastosis foetalis have been published by Diamond, Blackfan and Baty,1 by Hueper and Mullen,2 by Capon3 and by others; hence an attempt will not be made to present an exhaustive discussion of the subject.

The main facts are as follows: There are three conditions which appear quite unlike clinically but which exhibit the same blood picture of excessive hemolysis and of abnormal hemopoiesis. These conditions are hydrops foetalis, fatal icterus of the newborn and congenital anemia. Infants with any of these diseases show some or all of the following symptoms: enlargement of the heart, liver