In 1905 Darling,1 while engaged in a search for leishmaniasis in the Panama Canal Zone, encountered a case of obscure splenomegaly in a Martinique Negro. Smears and sections of the organs revealed an organism strongly suggestive of the Leishman-Donovan body. Darling recognized certain morphologic characteristics differentiating this organism from the causative agent of kala-azar, but because of its resemblance he felt that this, too, was a protozoan, and he therefore named it "Histoplasma capsulatum." Subsequently he described 2 other cases.2 Darling's material was studied in 1912 by da Rocha Lima,3 who expressed the opinion that these were instances of fungous infection simulating the epizootic lymphangitis of horses due to Cryptococcus farciminosus (Rivolta). Later4 Darling was said to have concurred in this impression. No other case reports appeared in the literature until 1926, when Watson and Riley5 uncovered comparable organic changes in postmortem examination of a
AGRESS H, GRAY SH. HISTOPLASMOSIS AND RETICULOENDOTHELIAL HYPERPLASIA. Am J Dis Child. 1939;57(3):573–589. doi:10.1001/archpedi.1939.01990030087010
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