That erythema nodosum, as a rule, is a tuberculous symptom complex is undoubted. This has been indicated by previous observations. Decisive evidence of it was given in the investigation described by one of us (H. E.1) at the first Northern Congress for Pediatrics, held in Copenhagen in 1919, and later presented in a more explicit form. In a number of cases of erythema nodosum it was demonstrated not only that all the patients reacted positively to tuberculin but that the source of the symptom complex lay in a tuberculous focus. In the greater number of cases this focus was localized in the bronchial glands and the lungs. Exceptionally there was localization in another region, such as the cervical lymph nodes. The investigations just mentioned threw a fresh light on a pathologic picture which until then had been obscure.
Some earlier investigations (especially Pollak's2 tuberculin tests in a number
ERNBERG H, GABINUS O. CLOSE SUCCESSION OF CASES OF ERYTHEMA NODOSUM OF NONTUBERCULOUS PATHOGENESIS. Am J Dis Child. 1939;57(5):1012–1025. doi:10.1001/archpedi.1939.01990050018002
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