Ratner, Jackson and Gruehl1 conclusively demonstrated intrauterine sensitization of the fetus of the guinea pig. They actively sensitized females with horse serum, and when these animals were bred with normal males, all of the offspring showed sensitivity to horse serum. This passive transmission of hypersensitiveness lasted from two and one-half to four months. Subsequently, Cohen and Woodruff2 confirmed these findings with guinea pigs, using egg white as the sensitizing antigen. The passively sensitized offspring were bred at from 3 to 6 months of age. About 50 per cent of the animals born of these matings showed sensitivity. Transmission of hypersensitiveness could not be demonstrated beyond this stage.
Ratner3 presented 15 cases of food allergy in children. In each of these cases the author stated that in the antepartum period the mother consumed unusually large amounts of certain foods and that some time after birth the offspring showed
ZOHN B. PLACENTAL TRANSMISSION OF HYPERSENSITIVENESS TO ASCARIS LUMBRICOIDES ACTIVELY INDUCED IN THE PREGNANT WOMAN. Am J Dis Child. 1939;57(5):1067–1071. doi:10.1001/archpedi.1939.01990050073007
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: