Tobacco sensitization has become a subject of increasing interest, owing largely to the investigations conducted by Harkavy and his co-workers. The first reports1 dealt with the occurrence of positive intracutaneous reactions to various tobacco antigens in 103 patients suffering from thromboangiitis obliterans (Buerger's disease). Sulzberger2 confirmed these findings in a total of 24 cases of a similar condition. Harkavy1 was the first to demonstrate successfully the existence of passive transfer reactions (Prausnitz-Küstner method) to tobacco. Later, with Witebsky,3 he showed that sensitization of the normal skin on passive transfer with serums obtained from tobaccosensitive patients could be inhibited by the previous absorption of the tobacco antibody in vitro. Quantitative titration of the tobacco antibody (reagin) in his patients disclosed a high degree of sensitivity to the tobacco extract employed. Quantitative titration of the antibodies for timothy and for tobacco was also made. Preliminary addition of timothy
PESHKIN MM, LANDAY LH. CUTANEOUS REACTIONS TO TOBACCO ANTIGEN IN ALLERGIC AND IN NONALLERGIC CHILDREN: WITH DIRECT AND INDIRECT (LOCAL PASSIVE TRANSFER) METHODS OF TESTING. Am J Dis Child. 1939;57(6):1288–1309. doi:10.1001/archpedi.1939.01990060068007
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