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This monograph is an analysis of the findings in 88 personally collected cases of granulocytopenia, together with pertinent data from the literature. The material is discussed under the usual headings—clinical symptoms, diagnosis, pathology, etc. Thirty-six autopsies are recorded, and detailed case histories are given. The main purpose of the author, however, is to elucidate the etiology of the disease.
Plum concludes that aminopyrine is the chief cause of granulocytopenia and that in Denmark, at least, it is nearly the only cause. He presents a considerable amount of new data in support of this contention. An analysis of the yearly incidence in Denmark shows a remarkably close correlation between the use of aminopyrine and the occurrence of the disease. Previous to 1922, when the drug began to be sold commercially on a large scale, only 3 unequivocal cases were reported or have been found on retrospective examination of hospital records. Of
Clinical and Experimental Investigations in Agranulocytosis, with Special Reference to the Etiology.. Am J Dis Child. 1939;57(6):1475–1476. doi:10.1001/archpedi.1939.01990060255024
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