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The seven chapters deal with the historical aspects of sulfanilamide therapy, the chemotherapy of experimental bacterial infections, the experimental toxicity and the comparative pharmacology of sulfanilamide and allied compounds, the mode of action of sulfanilamide and its derivatives, the clinical use of sulfanilamide, the clinical use of sulfapyridine, of sulfanilyl sulfanilamide and of benzylsulfanilamide, the clinical use of prontosil and neoprontosil and the clinical toxic manifestations of sulfanilamide and its derivatives. The book will be found most useful for its chapter on historical aspects and its many references. The authors were perhaps too dogmatic in their own views and too caustically critical of other workers in this field who have expressed opposing views. As usual with a rapidly advancing subject, the textbook which attempts to cover it is already almost out of date when published.