The role of the thyroid in calcium metabolism has been investigated by Aub and others1 with low calcium intake, and they have concluded that in cases of exophthalmic goiter and hyperfunctioning adenoma the excretion is increased and that in cases of myxedema it is markedly diminished and that the giving of thyroid to normal persons and to patients with myxedema increases the excretion. They expressed the belief that this was due to a direct stimulating effect on the calcium deposits in the bones. Their data on the patients with exophthalmic goiter were striking and definite; the figures on those with myxedema left some doubt. Thus, even allowing for the variation inherent in short term balances, when isolated figures are picked at varying metabolic levels the following are difficult to reconcile with their thesis:
Although many of the balances do show an increased output, they do not impress us as
JOHNSTON JA, MARONEY JW. FACTORS AFFECTING RETENTION OF NITROGEN AND CALCIUM IN PERIOD OF GROWTH: II. EFFECT OF THYROID ON CALCIUM RETENTION. Am J Dis Child. 1939;58(6):1186–1198. doi:10.1001/archpedi.1939.01990110050002
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