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December 1939

SEX RATIOS IN FAMILIES WITH HEMOPHILIA

Am J Dis Child. 1939;58(6):1215-1227. doi:10.1001/archpedi.1939.01990110079004
Abstract

So much has been written on the subject of hemophilia that it would appear rather improbable that anything is left to be said. The present study was undertaken because of curiosity aroused by the contradictory statements of Eley1 and of Birch2 as to alterations in the sex ratio found in families with hemophilia. Eley has said, "As if to further perpetuate the disturbance, transmitters of hemophilia usually have more daughters than sons." Birch has stated, "The children of transmitters of hemophilia are predominantly male; 63 per cent male and 37 per cent female, or about 1.7 males to every female.... A transmitter has an almost 2: 1 chance of having sons instead of daughters." And further on, she has said, "The children of persons with hemophilia are more apt to be female than male.... Nature seems to have provided that this disease shall go on forever, because the

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