During a seven month period 140 children with pneumococcic infections were treated with sulfapyridine. This group includes all of the patients with pneumococcic infections observed during this time with the exception of a child who received serum alone and a few children whose illness was so mild that no specific therapy was given. Three patients treated with sulfapyridine also received antipneumococcus rabbit serum. A few others received nonspecific supportive treatment in the form of blood transfusions and oxygen therapy in addition to sulfapyridine. Forty-nine children with nonpneumococcic infections who were treated with sulfapyridine will not be considered here except in the discussion of toxic manifestations.
A uniform dosage based on the weight of the child was adopted, though exceptions were made in several instances. Two hundred milligrams of the drug per kilogram of body weight was given in divided doses during the first day and 100 mg. per kilogram per