That serious and rather rare disease of the skin which Gottfried Ritter von Rittershain1 first studied in 1868 and described some ten years later continues to remain a subject of much controversy.2 Briefly, this disease occurs in early infancy, either sporadically or epidemically, and is characterized by rapidly spreading redness, vesicles and bullae, together with epidermolysis and exfoliation. The epidermolysis is probably the most characteristic finding.2a It is manifested as the peeling away of the uninvolved skin on the slightest rubbing or other trauma and the leaving of a raw, oozing surface. When the disease is mild this may be found around the bullae, and when the condition is severe, it may be found anywhere over the uninvolved skin. Figures for mortality vary. From his studies, which, incidentally, represent the largest series, Ritter von Rittershain1a reported a mortality of 50 per cent. Finkelstein3 reported a
RYAN NW, GOLDMAN L. TREATMENT OF RITTER'S DISEASE WITH SULFAPYRIDINE: REPORT OF A CASE WITH RECOVERY. Am J Dis Child. 1940;59(5):1057–1062. doi:10.1001/archpedi.1940.01990160129008
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