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November 1940


Author Affiliations

San Francisco.

Am J Dis Child. 1940;60(5):1172-1173. doi:10.1001/archpedi.1940.02000050156015

To the Editor:—The recent publication by Doull and his associates1 of the final results of their study of pertussis prophylaxis again brings out the sharp contrast between their results and those obtained by a number of other workers in the same field and renews the confusion felt by many physicians when attempting to judge the merits of vaccination against pertussis. The matter is one of prime importance in pediatrics and preventive medicine, since if vaccination for whooping cough is meritorious it should be generally employed. For this reason, we submit a brief summary of such published work as is now available.

Besides the work of Doull and his collaborators, there are seven separate studies2 which fulfil, as does the investigation of Doull and his associates, the following requirements: (1) The vaccine used was made from Haemophilus pertussis in phase 1 (Leslie-Gardner classification); (2) the total dosage was

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