Numerous investigations1 have shown that active immunization is of value in preventing clinical scarlet fever. However, it is true that scarlatina sine eruptione may occur. Despite the possibility of successful immunization and the fact that, as is recognized, scarlet fever has been a mild disease in late years, it still carries an average annual death rate of 3.5 per hundred thousand population in Illinois2 and frequently, even in the mild form, has serious complications and sequelae.
Hoyne stated3 that routine immunization against scarlet fever has not been employed by some men, however, because of the severity of local and systemic reactions and because of the multiplicity of injections required. As a result, many modifications have been suggested to overcome some of these disadvantages of the Dick method. Thus, attempts have been made to immunize against scarlet fever by the oral administration of the toxin4 and by
FISHER S, VAN GELDER DW. INTRADERMAL IMMUNIZATIONI. SCARLET FEVER. Am J Dis Child. 1941;61(1):88–98. doi:10.1001/archpedi.1941.02000070097008
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