Myasthenia gravis is an uncommon condition in childhood. The disease was first described by Willis1 in 1672 and was recognized by Erb2 as a clinical entity in 1878. The first case of the disease in childhood, described by Remak,3 was that of a 12 year old girl. The relative infrequency of the condition in patients under the age of 17 years is illustrated by statistics from the literature. Palmer,4 in reviewing the literature in 1908, found 8 such cases in a total of 126. Gerstle5 cited 2 cases of the condition in patients under 10 years of age and 12 cases in persons under 20 years of age among 67 cases observed at the National Hospital in London between 1900 and 1927, but apparently these cases have not been reported. Kennedy and Moersch6 noted that the onset of symptoms occurred in the second decade
LEVETHAN ST, FRIED AJ, MADONICK MJ. MYASTHENIA GRAVIS: REPORT OF A CASE IN WHICH PROSTIGMINE METHYLSULFATE WAS USED. Am J Dis Child. 1941;61(4):770–775. doi:10.1001/archpedi.1941.02000100104012
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