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Case Reports
April 1941


Author Affiliations

From the Philadelphia Institute for Medical Research, the Shriners' Hospital and the Philadelphia General Hospital, Pediatric Service of Dr. Edward Thorpe.

Am J Dis Child. 1941;61(4):776-794. doi:10.1001/archpedi.1941.02000100110013

Osteochondrodystrophia deformans, or Morquio's disease, is a skeletal disease starting probably during fetal life and characterized by (1) dwarfism, (2) deformities of the bones of the trunk and the extremities and (3) roentgen changes, consisting of absence of centers of ossification, destruction, rarefaction and proliferation involving all of the bones of the body except possibly those of the skull.

In 1929 Morquio1 described a form of osseous dystrophy occurring in 2 of a family of 5 children and reported 2 additional cases in 1935. In 1931 Ruggles2 described the roentgen findings in the bones in 8 similar cases, in 5 of which the condition was familial. Another case, that of a patient observed for more than seven years, was added in 1932 by Meyer and Brennemann.3 During the past eight years at least 25 new cases have been recorded in the literature under the name either of

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