In another publication1 I stated that tetanus antitoxin is best administered by the intravenous or the intramuscular route, in single doses of 40,000 to 60,000 units. In this paper attention is directed to a study of two lines of evidence which have been offered in support of the aforementioned method of treatment. The first consists of observations which indicate that tetanus toxin reaches the central nervous system directly by way of the blood stream, rather than by centripetal spread along the motor nerve trunks. The second reviews the observations made by me and by others which have shown that a single dose of 30,000 or more units of antitetanus serum, administered by the intravenous or the intramuscular route, is associated with an immunity which is adequate, both in level and in duration, to meet the indications imposed by a rational method of specific serotherapy.
PATHWAY BY WHICH TETANUS TOXIN
SPAETH R. SERUM THERAPY OF TETANUS: WITH SPECIAL REFERENCE TO THE COURSE OF ANTITOXIN TITERS IN THE BLOOD AFTER TREATMENT WITH SPECIFIC SERUM. Am J Dis Child. 1941;61(6):1146–1174. doi:10.1001/archpedi.1941.02000120018002
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