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October 1941


Author Affiliations

Captain, Medical Corps, United States Army; CHICAGO
From St. Vincent's Infant and Maternity Hospital, Chicago, and the Children's Hospital, Illinois Soldiers' and Sailors' Children's School, Normal, Ill.

Am J Dis Child. 1941;62(4):757-764. doi:10.1001/archpedi.1941.02000160058007

Active immunization against diphtheria is almost universally recommended by public health authorities and pediatricians.1 Since the introduction of this procedure for human use, by von Behring, many attempts have been made to reduce the pain and the untoward local or systemic reactions which it may cause as well as the number of injections which must be given without affecting the prolonged and effective immunity produced. For these reasons Ramon's anatoxin and later alum-precipitated toxoid were introduced to displace the toxin-antitoxin.

As in immunization against scarlet fever, numerous reports have been published concerning the use of methods other than the usual subcutaneous injection of toxoid for immunization against diphtheria. The percutaneous method recommended by Loewenstein gave conflicting results, according to the literature. Abt and Feingold2 reported a reversal of the Schick reactions of 70.9 per cent of their subjects by the use of this technic. Hamada3 observed no