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February 1942


Author Affiliations

From the department of Pediatrics (Endocrine Clinic) and the Institute for Juvenile Research, University of Illinois College of Medicine and the Research and Educational Hospital.

Am J Dis Child. 1942;63(2):238-251. doi:10.1001/archpedi.1942.02010020023003

Several hundred obese children have been referred to us as having Fröhlich's syndrome, or dystrophia adiposogenitalis. These patients were presumed to have pituitary disease or a combination of pituitary with thyroid involvement. Approximately 80 of this number1 have been studied thoroughly from the point of view of physical development (sexual and mensurational) (fundi and visual fields), and complete laboratory studies were made, including roentgenographic examination of the head (sella turcica), wrist and knee, and basal metabolism, blood cholesterol and sugar tolerance tests. In addition, we have used a roentgenographic cephalometric appraisal2 to study the problem further. Analysis of the craniofacial system by this method showed that in general the skeletal development in an unselected group of some 20 obese boys and girls was normal and even in advance of that in normal controls. We have also made cephalometric studies of thyroid-deficient3 and dwarfish4 (pituitary) children and so

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