In 1936 and 1938, 2 infants that died at the Babies Hospital within a month of their birth were found at autopsy to have an unusual type of encephalomyelitis. The disseminated inflammation was characterized by necrosis and miliary granulomas and was associated with focal chorioretinitis. It was evidently due to a specific protozoon, the identity of which was difficult to determine (Wolf and Cowen, 19371). The morphology of the causative micro-organism and the nature of the pathologic process induced by it soon suggested that the parasite was a Toxoplasma (Wolf and Cowen, 19382). This was confirmed by a study of the biologic characteristics of the micro-organism isolated in the second case (Wolf, Cowen and Paige, 1939, 19403). A previously recorded instance of retinal infection in an infant (Jankû, 19234) and an incompletely described case of congenital encephalomyelitis, myocarditis and myositis (Torres, 19275) had been reported
PAIGE BH, COWEN D, WOLF A. TOXOPLASMIC ENCEPHALOMYELITIS: V. FURTHER OBSERVATIONS OF INFANTILE TOXOPLASMOSIS; INTRAUTERINE INCEPTION OF THE DISEASE; VISCERAL MANIFESTATIONS. Am J Dis Child. 1942;63(3):474–514. doi:10.1001/archpedi.1942.02010030044004
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