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Case Reports
April 1942

LAURENCE-MOON-BIEDL SYNDROME: ITS OCCURRENCE IN A NEGRO CHILD; TREATMENT WITH GONADOTROPIN AND ANDROGEN

Author Affiliations

WASHINGTON, D. C.
From the Division of Pediatrics and the Division of Orthopedic Surgery, Howard University College of Medicine and Freedmen's Hospital.

Am J Dis Child. 1942;63(4):733-741. doi:10.1001/archpedi.1942.02010040101006
Abstract

The so-called Laurence-Moon-Biedl syndrome is a fairly rare1 condition characterized by six cardinal signs, namely obesity, atypical retinitis pigmentosa, mental deficiency, genital dystrophy, polydactylism and familial occurrence. In the literature a number of associated anomalies have been reported,2 such as genu valgum, coxa vara, scoliosis, shortness of the hands and feet, dwarfism, deformities of the skull, deafness, strabismus, nystagmus and congenital heart disease. All of the patients whose cases are described under this diagnosis do not present the complete classic syndrome. Thus of 102 patients data on whom were tabulated by Warkany, Frauenberger and Mitchell1b only 24 exhibited the complete syndrome. Males apparently are affected more often than females.

Although this condition was first described by Laurence and Moon3 seventy-five years ago, it remained for Bardet4 and Biedl5 to recognize

(Footnotes continued on next page) the symptom complex as constituting a distinct clinical syndrome.

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