A malignant tumor of the retina which occurs almost exclusively in infants and in young children would seem to be of primary concern to the pediatrician. Although malignant tumors in general are relatively infrequent in children, from the standpoint of mortality their significance is disproportionately great in comparison with other childhood diseases. About two thirds of the retinoblastomas which have been the subjects of the numerous reports in the world literature for more than a hundred and fifty years have been in children under 4 years of age. The appearance of such a highly malignant neoplasm in this early age period is a frightful catastrophe both to the patient and to the family. The full-blown clinical picture in the later stages of the growth's development is replete with tragic and horrible manifestations. This is a tumor the efficacy of treatment for which is dependent for the most part on early
NICHAMIN SJ. RETINOBLASTOMA OF INFANTS AND CHILDREN: ITS SIGNIFICANCE AS A PEDIATRIC PROBLEM. Am J Dis Child. 1942;63(5):945–953. doi:10.1001/archpedi.1942.02010050109012
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