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Progress in Pediatrics
July 1942

SERUM SICKNESS AND ANAPHYLAXIS: ANALYSIS OF CASES OF 6,211 PATIENTS TREATED WITH HORSE SERUM FOR VARIOUS INFECTIONS

Author Affiliations

NEW YORK
From the Willard Parker Hospital.

Am J Dis Child. 1942;64(1):93-143. doi:10.1001/archpedi.1942.02010070094011
Abstract

TABLE OF CONTENTS 

  • Fatal Cases

  • Factors Influencing the Incidence of Serum Sickness and Anaphylaxis

    • Kind of Serum

    • Age and Sex

    • Race

    • Amount of Serum Injected

    • Route of Administration

    • Preparation of Serum

    • Age of Serum

    • Horse Producing Serum

    • Repeated Injections

  • Serum Sickness in Animals

  • Serum Rash

    • Types

    • Recurrence

  • Onset of Serum Sickness

  • Duration of Serum Sickness

  • Symptoms of Serum Sickness

    • Fever

    • Edema

    • Adenopathy

    • Arthritis

    • Gastrointestinal Tract Complications

    • Respiratory System Complications

    • Cardiovascular-Renal Complications

    • Endocrine Complications

    • Mental Complications

    • Central Nervous System Complications

    • Peripheral Nervous System Complications

  • Miscellaneous Complications

  • Secondary Injections

    • Passive Sensitization to Horse Serum Transferred Through the Use of Human Convalescent Serum

    • Arthus Phenomena Reported in the Literature

  • Diagnostic Intradermal Test

    • Classification of Persons Giving Positive Reactions to the Intradermal Test

    • Route Factor

    • Cases of Spontaneous Sensitivity

    • Positive Reactions to Intradermal and Conjunctival Tests Reported in the Literature

  • Diagnosis

  • Mechanism

  • Prevention

  • Treatment

    • Thermal Reaction

  • Comment

  • Summary and Conclusions

As late as 1932 Park1 claimed that the mortality from serum anaphylaxis was only 1 in 50,000, a ratio which is still quoted by almost all American writers, e. g. Coca,2 Taylor,3 Mackenzie and Hanger,4 Cooke5 and Zinsser.6 In Europe Pfaundler's7

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