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Progress in Pediatrics
August 1942

SERUM SICKNESS AND ANAPHYLAXIS: ANALYSIS OF CASES OF 6,211 PATIENTS TREATED WITH HORSE SERUM FOR VARIOUS INFECTIONS

Am J Dis Child. 1942;64(2):313-350. doi:10.1001/archpedi.1942.02010080107012
Abstract

(Concluded from p. 143)

MISCELLANEOUS COMPLICATIONS  About 2 per cent of the patients had chills, which were never severe and were followed by a rise in temperature of 2 to 4 degrees (F.) above normal. Usually the chills appeared just prior to the rash or soon after. Fischer179 observed a child born dead to a normal mother ill with serum sickness. Necropsy showed petechial hemorrhages. In a similar case of his, the child survived sixteen hours and autopsy revealed profuse hemorrhages in the brain, the kidneys and the adrenal capsules. Brown180 reported the only blood dyscrasia; it developed immediately after an attack of accelerated serum sickness in a previously healthy 14 year old boy who received a prophylactic inoculation of tetanus serum. He had received a similar injection of tetanus serum two years before. He died in four weeks, with generalized adenopathy, splenomegaly and a white blood cell

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