In 1823 a case of chloroma was first reported by Allan Burns. In 1893, on the basis of the blood picture, Dock 1 first pointed out the relationship of chloroma and leukemia, and in 1904 Dock and Warthin2 definitely established this relationship. They defined chloroma as "a tumor-like hyperplasia of the parent-cells of the leucocytes, primary in the red marrow, the periosteum being involved only secondarily." Ewing3 has further emphasized the tumor-like properties of the process by stating that "the chief significance of chloroma lies in the fact that it represents a leukemic process of a pronounced neoplastic type. The bulky tumors, the destructive local infiltrations, the distant heterotopic metastases, the atypical character of the cells and their very active proliferation provide all the essential features of a malignant neoplasm." In 1930 Washburn4 had collected 162 cases from the literature between 1923 and 1929. In 1937 Kandel
BRAKELEY E. LEUKEMIA RESEMBLING CHLOROMA. Am J Dis Child. 1942;64(4):689–696. doi:10.1001/archpedi.1942.02010100115011
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