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December 1942

CREATINURIA IN INFANCY AND IN CHILDHOOD: II. CREATINURIA OF PREMATURE INFANTS

Author Affiliations

NEW YORK
From the New York Hospital and the Department of Pediatrics, Cornell University Medical College.

Am J Dis Child. 1942;64(6):996-1007. doi:10.1001/archpedi.1942.02010120036003
Abstract

Paffrath and Ohm1 in 1933 reported the virtual absence of creatine in the urine of premature infants, and Levine and I2 also found little or no creatine in casual specimens of urine from 6 premature infants who were receiving human milk. These subjects differed from full term infants receiving cow's milk, who excreted creatine in amounts ranging from 6 to 49 per cent of the total creatinine excretion.2

Studies of the daily creatine and creatinine excretion of premature infants who were receiving formulas of human or cow's milk and of full term infants of comparable age receiving cow's milk form the basis of the present report. The assembled data permit an analysis of the effect of protein intake on the creatine and creatinine excretion of premature and full term infants fed similar amounts of protein in the form of cow's milk.

METHODS AND MATERIAL  Subjects.—Forty healthy

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