In the treatment of gonorrheal vulvovaginitis there are three general lines of attack: (1) application of a local antiseptic; (2) administration of an endocrine substance and (3) chemotherapy with a sulfonamide compound. The present study was begun in an effort to determine whether the first, which has often been thought to be obsolete, would not be as effective as either of the others if continuous medication could be employed. For this purpose silver picrate, which has been used successfully in the past in the treatment of gonorrheal vaginitis1 and urethritis2 as well as vaginitis due to Trichomonas vaginalis,3 was chosen as the antiseptic. Infant size vaginal suppositories of silver picrate4 were used for all patients treated in the clinic during the period of study. Results for all these patients are included in this report with the exception of those who transferred or lapsed before they had