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The problem of duodenal ulcers in children was first made known to the medical profession when, in 1901, Adriance1 published a report of a case, including the clinical and postmortem observations. During the next few years data were accrued, in reports of autopsies and of cases indicating that the disease occurred more frequently than had been thought. Gerdine and Helmholz2 found duodenal ulcers in 8 of 16 autopsies on "atrophic" infants. In 1913 Entz reported that 10 duodenal ulcers were observed in autopsies on 364 unselected infants under 1 year of age. In 1913 Holt3 published a brilliant survey of the literature. Of the peptic ulcers reported in the series of cases analyzed by him, duodenal ulcers were most common. Of 65 patients 46, or 70 per cent, were between 6 weeks and 15 months of age; the condition occurred with the greatest frequency between the sixth
MEISELAS LE, RUSSAKOFF AH. BLEEDING PEPTIC ULCER IN INFANCY. Am J Dis Child. 1944;67(5):384–386. doi:10.1001/archpedi.1944.02020050046009
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