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Prior to the introduction of the sulfonamide compounds pneumococcic meningitis was almost invariably fatal. With the advent of these drugs, particularly sulfapyridine and sulfadiazine, the prognosis for patients with meningitis of this type was considerably improved. The introduction of penicillin marked another advance in the treatment of this disease. However, the number of reported recoveries from pneumococcic meningitis following penicillin therapy has up to the present time remained small. It has therefore seemed worth while to place on record our case, admission revealed an injected pharynx and a temperature of 102.6 F. Sulfadiazine was prescribed, but after the first dose of the drug a generalized convulsion supervened, lasting thirty or forty minutes. Sulfadiazine therapy was discontinued. The infant's condition remained stationary for the next twenty-four hours. However, the convulsions recurred the next morning, and the infant was brought to the emergency room of the hospital.
The history of the birth,
LITVAK AM, APPELBAUM E, GREENE M. PNEUMOCOCCIC MENINGITISCOMPLETE RECOVERY OF A SIX MONTH OLD INFANT TREATED WITH PENICILLIN. Am J Dis Child. 1944;67(6):485–486. doi:10.1001/archpedi.1944.02020060058010
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