That sulfonamide compounds have proved themselves of great value in the therapy of various infections no longer requires experimental or clinical brief. Nevertheless, their increasing popularity among physicians in general and the. introduction of new derivatives have emphasized the necessity for clarifying at least two important problems bearing on the ultimate value of these drugs. On the one hand, the question has been raised whether the repeated administration of sulfonamide drugs in successive infections in the same patient may in some way lessen their therapeutic effectiveness. On the other hand, anxiety has been expressed not only that repeated application of the different derivatives might have a cumulative injurious effect on various organs and tissues but that it might even create in time a sensitized population unable to take the drugs safely. Evidences of sensitization have been frequently reported, and the manifold manifestations ascribed to this reaction include histologic changes in
SIEGEL M. EFFECTS OF REPEATED USE OF SULFADIAZINE FOR RECURRING ACUTE INFECTIONS OF THE RESPIRATORY TRACT. Am J Dis Child. 1944;68(1):23–27. doi:10.1001/archpedi.1944.02020070030007
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