The phenomena of fits or convulsions have been observed in human beings and in animals throughout the ages, but the primary cause or causes of such convulsions are as yet not understood. The study of disease produced at will in animals has been in many cases of inestimable value in promoting a clearer understanding of the disease processes in human beings. Numerous attempts have been made to produce in animals changes which lead to convulsive phenomena. Some of these attempts have been eminently successful in producing a single convulsion or a short series of convulsions. The use of insulin, metrazol, thujone, electric shock, strychnine and so forth for this purpose is well known. There is, however, no accepted satisfactory method for producing in animals a series of spontaneous convulsive seizures such as occurs in patients suffering from epilepsy. It was in the hope of discovering such a method that the
KEITH HM, ESSEX HE, SCHLOTTHAUER CF. CONVULSIONS EXPERIMENTALLY PRODUCED IN DOGS. Am J Dis Child. 1944;68(4):265–268. doi:10.1001/archpedi.1944.02020100037008
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