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Case Reports
November 1944

HEMOLYTIC ANEMIA IN INFANCYREPORT OF A CASE WITH DEMONSTRATION OF HEMOLYTIC ACTIVITY OF SERUM

Am J Dis Child. 1944;68(5):327-329. doi:10.1001/archpedi.1944.02020110028006
Abstract

Recently a case of recurrent acute hemolytic anemia in a 4½ month old infant was observed in the pediatric service of Vanderbilt University Hospital.1 During a hemolytic crisis it was possible to demonstrate hemolytic activity of the patient's serum against his own red blood cells as well as against those of another patient of the same blood group. After splenectomy the patient made a complete recovery. This was associated with disappearance of the hemolytic activity of his blood serum.

During infancy recurrent hemolytic anemia, accompanied by slight icterus and enlargement of the spleen, is uncommon. In pediatric literature this condition has been classified as a form of the disease which is variously referred to ascongenital hemolytic icterus, congenital hemolytic anemia and familial spherocytosis. However, the usual criteria by which a diagnosis of congenital hemolytic anemia is established may not all be present in the infant. In addition, the clinical

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