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Case Reports
March 1945

MALIGNANT HYPERTENSION; CURE FOLLOWING NEPHRECTOMY: FOLLOW-UP REPORT OF THE CASE OF A CHILD

Author Affiliations

ROCHESTER, MINN.
Section on Pediatrics, the Mayo Clinic.; Division of Medicine, the Mayo Clinic.

Am J Dis Child. 1945;69(3):160-162. doi:10.1001/archpedi.1945.02020150021004
Abstract

During the last decade, 1934 to 1944, much clinical interest and experimental effort have been centered on unilateral atrophic pyelonephritis and renal ischemia as causative factors in the production of hypertension. Shortly after the report of the experimental observations of Goldblatt and his associates1 in 1934 on the production of persistent elevation of systolic blood pressure by means of renal ischemia, there appeared in the literature numerous accounts of the results of nephrectomy in cases of unilateral renal disease and hypertension. Immediate reduction in blood pressure occurred in a considerable number of cases. However, Barker and Walters2 in 1940 pointed out that although the immediate results in a number of cases were good, the ultimate result of nephrectomy in some cases was not satisfactory with regard to permanent lowering of the blood pressure.

In 1941 we3 reported the case of a girl, 7 years of age, who

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