The therapeutic problems presented by congenital pancreatic deficiency form two groups, those relating to nutrition and those presented by the characteristic infections of the respiratory tract. It is possible that the susceptibility to infection is a sequel to the difficulty in digestion. The present study was begun in the hope that a dietary regimen might be worked out which would result in adequate nutrition and growth and in improved resistance to pulmonary infection.
For nearly a hundred years it has been known that when pancreatic secretion is excluded from the intestine digestion is impaired and that pancreatic ferments are required for normal digestion of three of the main constituents of food, protein, starch and fat. Moreover, it has been found possible to maintain adult pancreatectomized dogs in good health by selection of diet, addition of vitamins and of raw pancreas to the diet and use of insulin.1
ANDERSEN DH. CELIAC SYNDROME: II. FECAL EXCRETION IN CONGENITAL PANCREATIC DEFICIENCY AT VARIOUS AGES AND WITH VARIOUS DIETS, WITH DISCUSSION OF THE OPTIMAL DIET. Am J Dis Child. 1945;69(4):221–230. doi:https://doi.org/10.1001/archpedi.1945.02020160021004
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