Chronic myelogenous leukemia is uncommon in childhood and rare in infancy. The disease seldom occurs in infants less than 6 months of age. In 1933, Cooke1 reported 3 cases encountered in the St. Louis Children's Hospital during a period of fifteen years. The patients were 8 years old or older. Poncher, Weir and Limarzi,2 in 1942, surveyed the literature and found only 2 cases of myelogenous leukemia which they thought could be considered chronic and in which the disease had its onset in early infancy. These 2 cases had been reported by Solmitz3 and Malmberg4 in 1924. Poncher, Weir and Limarzi reported 1 case of their own in which the disease was thought to be of congenital origin. The diagnosis was made when the infant was 6 weeks old. Death occurred at the age of slightly more than 3 months; hence the child was under observation
KEITH HM. CHRONIC MYELOGENOUS LEUKEMIA IN INFANCY. Am J Dis Child. 1945;69(6):366–368. doi:10.1001/archpedi.1945.02020180030005
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