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August 1945


Author Affiliations

From the Departments of Surgery of the Harvard Medical School and the Children's Hospital.

Am J Dis Child. 1945;70(2):61-73. doi:10.1001/archpedi.1945.02020200003001

Arterial thrombosis and arterial embolism are well recognized entities in adult patients and have received extensive consideration in medical journals and textbooks. Little attention has, however, been paid to such vascular occlusions in young subjects, particularly infants.

Dohan1 made an excellent review of the literature on gangrene of the extremities in the new-born, and much of the information included in the accompanying table was compiled from the data which he gathered. Heller and Alvari2 likewise presented an admirable review of gangrene of the extremities in newly born babies. Martin and Shore3 studied 4 patients, ranging in age from 4 to 14 years, with gangrene of the extremities. These writers particularly emphasized the role of severe sepsis in production of arterial thrombosis in children. Their discussion centered principally on lesions of older subjects and had little to do with infants. Von Khautz4 collected a group of 50