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February 1946


Am J Dis Child. 1946;71(2):150-161. doi:10.1001/archpedi.1946.02020250040004

IN DISTURBANCES of carbohydrate metabolism it is not uncommon for hyperglycemia and glycosuria to be interpreted as diabetes mellitus, while the extrapancreatic melliturias are overlooked. It seems worth while, therefore, to report an instance of hepatic diabetes occurring prominently in association with a rare case of biliary cirrhosis. The unusual features of hepatic diabetes associated with congenital biliary cirrhosis without obstruction of the extrahepatic bile ducts and with concomitant renal involvement, are, accordingly, considered. The value of the intravenous dextrose tolerance test1 in differentiating between pancreatic and hepatic diabetes is also discussed.

REPORT OF A CASE  The patient, R. K., admitted to The Children's Memorial Hospital at 2 months of age, was the product of a full term, normal pregnancy. His birth weight was 6 pounds 13 ounces (3,090 Gm.). He was breast fed for only the first four days of life, at which time jaundice became apparent. A