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July 1946

RESISTANCE OF COTTON RATS TO THE VIRUS OF POLIOMYELITIS: As Affected by Intake of Certain Purified Vitamins and by Sex

Author Affiliations

Department of Anatomy, Wayne University College of Medicine DETROIT

Am J Dis Child. 1946;72(1):6-16. doi:10.1001/archpedi.1946.02020300013002

A NUMBER of clinical studies have indicated that victims of the virus of poliomyelitis are apparently the healthier, the better nourished and the more robust members of the family. Since, among other factors, an adequate intake of vitamins is a necessary prerequisite for health, it was thought advisable to determine whether or not an increased intake of vitamins would influence the susceptibility of the host to the virus.

For this purpose a number of experiments were designed to test the effects of hypervitamin diets and of sex on the susceptibility and on certain immunologic responses of cotton rats to the virus of poliomyelitis. The present communication records the results of this investigation.

MATERIALS  The Armstrong-Lansing strain of the virus of poliomyelitis which has been adapted to the cotton rat was employed in these studies. The unfiltered, lightly centrifuged suspensions of the virus were prepared exclusively from the brain stems and