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July 1946

CELIAC SYNDROME: V. Genetics of Cystic Fibrosis of the Pancreas With a Consideration of Etiology

Am J Dis Child. 1946;72(1):62-80. doi:10.1001/archpedi.1946.02020300069004
Abstract

THE etiology of cystic fibrosis of the pancreas is an unsolved problem. It is not only an interesting puzzle in the abstract but a matter of practical importance, since any hope which there may be of decreasing the incidence of the disease depends on an understanding of its cause. Suggestions as to the causation have included the following: It may be a hereditary disease;1 it may be the result of a dietary deficiency during pregnancy or early infancy1b; it may be the result of intrauterine infection2 or of infection during early infancy. The more immediate mechanism of the production of the changes in the pancreas has also been attributed to obstruction of the large or small ducts1b or to some abnormality of the secretion of the acinar cells,3 with an abnormal viscosity of their products.4 There is general agreement as to one attribute of

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