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August 1946

CAUSES OF PREMATURITY: VIII. Influence of Infections, Chronic Disorders and Accidents on the Incidence of Prematurity

Author Affiliations

From the Children's Hospital Research Foundation and the Department of Pediatrics, University of Cincinnati College of Medicine.

Am J Dis Child. 1946;72(2):189-201. doi:10.1001/archpedi.1946.02020310055004

IN PREVIOUS reports the association of maternal syphilis, toxemia and uterine bleeding with the incidence of premature delivery has been investigated. There remains a number of other infections and chronic disorders less frequently encountered during pregnancy which may have an influence on the length of the gestation period. Certain conditions, such as tuberculosis and heart disease, have been singled out by other authors as specific factors contributing to premature delivery. In 13 reports in the literature1 the incidence of tuberculosis among the mothers of premature infants varied from 0.2 to 5.5 per cent. Fourteen authors observed that the incidence of heart disease among mothers of premature infants ranged from 0.1 to 8.3 per cent. Other acute and chronic conditions noted by seventeen authors were found to occur in percentages varying from 1.4 to 16.3.

The incidence of these diseases in our series of 13,526 mothers and infants was too

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