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Case Reports
September 1946

HEMOLYTIC DISEASE OF THE NEWBORN (ERYTHROBLASTOSIS FETALIS): Treatment by a Single Massive Transfusion, with Complete Recovery

Author Affiliations


Am J Dis Child. 1946;72(3):320-324. doi:10.1001/archpedi.1946.02020320071008

INFANTS with hemolytic disease of the newborn (erythroblastosis fetalis) receiving transfusions of Rh-negative blood have been shown to have a normal survival of the transfused Rh-negative cells, but when they are given transfusions of Rh-positive cells a rapid destruction of those cells occurs.1 In addition there seems to be some slowing down of the rate of hemolysis of the infant's Rh-positive cells when the transfusion is with Rh-negative blood, whereas this does not occur when a transfusion of Rh-positive blood is given. The present case report of an infant with hemolytic disease of the newborn who received an accidental massive transfusion of Rh-negative blood is offered as shedding some light on the presence of an anti-Rh antigen-antibody reaction factor in Rh-negative blood.

REPORT OF A CASE  C. D. F., a boy weighing 8 pounds 13 ounces (3,997 Gm.), was delivered by cesarean section at St. Joseph's Infirmary, Houston, Texas,

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