THE use of penicillin and the sulfonamide compounds is the inability to determine the duration of treatment necessary to eradicate an infection. This difficulty is due to the rapid disappearance of all clinical evidence of the disease before a cure has been completed. The so-called masking of symptoms is responsible for the premature discontinuance of medication. Recurrences of infection result not infrequently, and two or three courses of treatment may be required before recovery finally ensues. Spink and Hall1 emphasized that this problem creates two potential dangers, namely, that an infection may be controlled but not eradicated and that drug-resistant strains of organisms may develop and may be disseminated. In the treatment of mild infections of the respiratory tract, lymphadenitis and low grade cutaneous infections with cellulitis, a relapse represents more of an annoyance to the patient than a matter of serious import, as the ultimate prognosis is almost invariably
ROTHMAN PE. RECURRENCE OF INFECTION FOLLOWING THERAPY WITH SULFONAMIDE COMPOUNDS AND PENICILLIN. Am J Dis Child. 1946;72(4):415–420. doi:10.1001/archpedi.1946.02020330047007
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