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April 1947

JUVENILE OSTEOPETROSIS: Metabolic Studies in Two Cases and Further Observations on the Composition of the Bones in This Disease

Author Affiliations

From the Pediatric Department of the Jewish Hospital of Brooklyn.

Am J Dis Child. 1947;73(4):458-472. doi:10.1001/archpedi.1947.02020390070004

REPORTS of cases of osteopetrosis have hitherto dealt mostly with the clinical and pathologic aspects of this disease. Studies of the mineral balance and chemical analyses of the bones have been few in number. Laurell and Wallgren1 were first to study the calcium balance in a 12 year old child suffering from osteopetrosis. They found positive calcium balances in all periods studied and "no tendency towards an abnormally high retention of calcium." Flood2 found a positive calcium balance and a normal partition of this element between the urine and the stools in his case (the patient was a 12 year old girl). An outstanding observation in his case was of the presence of hypercalcemia. Bernhardt3 found in a 26 year old man a slightly negative calcium balance which became positive on the addition of tertiary calcium phosphate to the diet. The composition of the diet (with respect to

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