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May 1947

SERUM LEVELS OF VITAMIN A IN CHILDREN: A Comparison Following the Oral and Intramuscular Administration of Vitamin A in Oily and in Aqueous Mediums

Author Affiliations

From the Pediatric Research Laboratory and the Pediatric Department of The Jewish Hospital.

Am J Dis Child. 1947;73(5):543-553. doi:10.1001/archpedi.1947.02020400014002

BLACKFAN and Wolbach1 have reported that "histologic evidences of A avitaminosis may occur in infants who are receiving an amount of vitamin A in their diet usually accepted as meeting the minimal protective needs of the body." Similar histologic changes have been observed by one of us (B. K.) in children with chronic diarrhea and cystic fibrosis of the pancreas who received amounts of vitamin A much larger than the considered adequate dose.

It has been shown by May and his colleagues2 and Chesney and McCoord3 that impaired intestinal absorption of vitamin A exists in children with celiac disease, cystic fibrosis of the pancreas, obliteration of the bile ducts and cretinism.

In an effort to circumvent this barrier to the absorption of vitamin A, the latter was administered by intramuscular injection.4 Although McCoord and Breeze5 obtained an elevation of the vitamin A level in the

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