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July 1947

ORAL ADMINISTRATION OF PENICILLIN IN PEDIATRICS

Am J Dis Child. 1947;74(1):19-31. doi:10.1001/archpedi.1947.02030010026003
Abstract

PART 1 

A. INTRODUCTION  AT PRESENT there are many commercial preparations of penicillin for oral use. Unfortunately, there are conflicting opinions as to its efficacy. This is evidenced in part by the existing disagreement in the literature and likewise by the lack of uniformity of directions for dosage and administration.Several children have been admitted to the wards of Queens General Hospital with advanced pyogenic diseases of various types after ineffective oral treatment with penicillin at home. The causative organisms in these cases frequently are made more resistant to penicillin administered parenterally by inadequate oral treatment. This form of treatment does more harm than good. Preparations of penicillin for oral administration are being used for the initial treatment of these patients, despite the fact that the Food and Drug Administration has approved oral use of this drug only for cases in which the disease is already "under control" after parenteral

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