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Case Reports
October 1947

PNEUMOCOCCIC MENINGITIS: Recovery of An Infant Twenty-Five Days of Age Treated with Sulfadiazine and Penicillin

Am J Dis Child. 1947;74(4):481-486. doi:10.1001/archpedi.1947.02030010494008
Abstract

IN THE era preceding introduction of the sulfonamide drugs the mortality rate of pneumococcic meningitis was almost 100 per cent.1 With the advent of these antibacterial drugs, numerous cases of recovery from this type of meningitis have been reported. Thus, with the use of the sulfonamide drugs, the mortality rate had dropped to levels varying from 332 to 66 per cent.3

Recently, even more favorable results have been reported in the treatment of pneumococcic meningitis with the combined administration of penicillin and sulfadiazine. Waring and Smith4 observed only 1 death among 13 patients; Hutchins and Davies5 reported 4 deaths among 14 children, and Smith, Duthie and Cairns6 had 9 deaths among 38 patients treated with sulfadiazine and penicillin.

In spite of the sharp drop in the mortality rate following the advent of chemotherapy, the occurrence of this disease in infants under 3 months of

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