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August 1948

MOTHER-CHILD ABO INCOMPATIBILITY: A Relation of Secretor Status to Mental Deficiency

Author Affiliations

From the Southbury Training School and th Department of Pediatrics, Yale Medical School.

Am J Dis Child. 1948;76(2):176-183. doi:10.1001/archpedi.1948.02030030185004

MOTHER-CHILD ABO incompatibility occurs in about 20 per cent of all pregnancies.1 Instances of fetal injury due to ABO maternal isoimmunization, while recognized in increasing numbers,2 are, however, relatively infrequent. A theoretically protective mechanism was suggested by the observation that in a large majority of persons, the A or the B factor is present in significant concentration in the body fluids.3 Thus, abnormally stimulated A or B agglutinins transmitted from the mother to the child as a result of isoimmunization could be rapidly neutralized without resulting in tissue damage or destruction of red blood cells. The differentiation of persons normally exhibiting the A or the B factor in their body fluids (secretors) from those in whom the factor is absent or present in relatively insignificant amounts (nonsecretors) was first made by Schiff and Sasaki.4 Our interest in this aspect of the problem of isoimmunization was further

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