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September 1948

EXPERIMENTAL TOXOPLASMOSIS: I. Transmission of the Infection in Utero and Through the Milk of Lactating Female Mice

Author Affiliations

From the New York Hospital and the Department of Pediatrics, Cornell University Medical College.

Am J Dis Child. 1948;76(3):307-315. doi:10.1001/archpedi.1948.02030030317003

THE PROTOZOON toxoplasma has long been known to be pathogenic to a large variety of mammals and birds,1 but interest in the organism was aroused only when Wolf, Cowen, and Paige2 firmly established that the parasite causes a disease in human infants. Pinkerton and Weinman3 subsequently showed that not only infants but also adults can have toxoplasmosis, a disease marked by variable clinical and subclinical manifestations. In very young children and babies, hydrocephalus, microcephaly, chorioretinitis, cerebral calcifications and psychomotor disturbances are observed most commonly,4 while in older children acute, nonsuppurative encephalitis is also seen.5 Relatively few cases of the disease in adults have been reported. A spotted-fever-like syndrome associated with atypical pneumonia appears to be the cardinal sign of the acute disease,6 while chorioretinitis is probably a manifestation of a more chronic course.7 There is now a considerable body of evidence to indicate

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