THE ETIOLOGIC basis of rheumatic fever is at present unknown. Since the disease is in all likelihood an infectious one, many direct bacteriologic and virologic studies on it have been carried out in recent decades. None of these studies has identified any organism responsible for the phenomena of this disease. Epidemiologic observations have, however, given indications of some relation between rheumatic fever and infection by the hemolytic streptococcus. These studies were critically reviewed by Paul and associates.1
The suggested relation between hemolytic streptococcic infection and rheumatic fever, in the absence of bacteriologic identification, led to a large volume of work in which attempts were made to identify or evaluate the role of this organism in rheumatic fever by immunologic tests. A few studies of cutaneous sensitivity to streptococcic materials were carried out, but the great majority of the immunologic work reported dealt with serologic investigations. It is the latter
HARRIS TN. STUDIES ON THE RELATION OF THE HEMOLYTIC STREPTOCOCCUS TO RHEUMATIC FEVER: I. Review of Serologic Literature. Am J Dis Child. 1948;76(4):411–422. doi:10.1001/archpedi.1948.02030030423006
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: