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Progress in Pediatrics
October 1948

STUDIES ON THE RELATION OF THE HEMOLYTIC STREPTOCOCCUS TO RHEUMATIC FEVER: I. Review of Serologic Literature

Author Affiliations

PHILADELPHIA
From The Children's Hospital, Philadelphia (Department of Pediatrics, University of Pennsylvania School of Medicine), the Children's Seashore House at Atlantic City (N. J.) for Invalid Children and the Philadelphia General Hospital.

Am J Dis Child. 1948;76(4):411-422. doi:10.1001/archpedi.1948.02030030423006
Abstract

THE ETIOLOGIC basis of rheumatic fever is at present unknown. Since the disease is in all likelihood an infectious one, many direct bacteriologic and virologic studies on it have been carried out in recent decades. None of these studies has identified any organism responsible for the phenomena of this disease. Epidemiologic observations have, however, given indications of some relation between rheumatic fever and infection by the hemolytic streptococcus. These studies were critically reviewed by Paul and associates.1

The suggested relation between hemolytic streptococcic infection and rheumatic fever, in the absence of bacteriologic identification, led to a large volume of work in which attempts were made to identify or evaluate the role of this organism in rheumatic fever by immunologic tests. A few studies of cutaneous sensitivity to streptococcic materials were carried out, but the great majority of the immunologic work reported dealt with serologic investigations. It is the latter

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