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January 1949

WHOOPING COUGH TREATED WITH PERTUSSIS IMMUNE SERUM (HUMAN): Report on a Controlled Series of Fifty-Two Patients Under One Year of Age

Author Affiliations

From the Philadelphia Hospital for Contagious Diseases.

Am J Dis Child. 1949;77(1):15-24. doi:10.1001/archpedi.1949.02030040022002

THE TREATMENT of whooping cough is a problem which still presents a challenge. Its high mortality and severity in the younger age group have focused attention of physicians on this disease in an effort to find better ways to treat it. Until about ten years ago, the treatment of whooping cough was entirely symptomatic, but at present, with the use of convalescent serum and immune whole blood, the employment of potent or high titer serums is encouraged. These serums are obtained from human beings, or from rabbits, who have been repeatedly immunized with pertussis vaccine.

Bradford,1 in 1935, using immune blood from patients, concluded that it was probably effective in the prevention and modification of whooping cough if given before the catarrhal symptoms appear. The benefit was less apparent when given after the disease was established.

Using the opsonocytophagic index and the decrease in the number of lymphocytes as

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