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Progress in Pediatrics
March 1949

METHODS OF BCG PRODUCTION AND VACCINATION

Author Affiliations

CHICAGO
From the Tice Laboratories and Clinic of the City of Chicago Municipal Tuberculosis Sanitarium and the University of Illinois.

Am J Dis Child. 1949;77(3):377-380. doi:10.1001/archpedi.1949.02030040387011
Abstract

IN A REPORT by the United States Public Health Service,1 as well as in one made for the British government,2 it was agreed that BCG production should be carried out by a central laboratory. The reasons for this universal agreement were: (1) to afford a standard method of comparison; (2) to maintain the fastidiousness of the organism; (3) to guarantee the minute care necessary in production of the vaccine, as the final product is a living organism to which no preservative can be added, and (4) to insure accurate and careful determination of the virulence.

If such a program is followed, the results of vaccination in human subjects in various parts of the country can be readily correlated and the stability of the organisms assured.

HISTORIC ASPECTS  A review of the literature reveals that "accidents" have occurred when central laboratories well qualified to produce the vaccine were not

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