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Progress in Pediatrics
March 1949


Author Affiliations

From the Tice Laboratories and Clinic of the City of Chicago Municipal Tuberculosis Sanitarium and the University of Illinois.

Am J Dis Child. 1949;77(3):377-380. doi:10.1001/archpedi.1949.02030040387011

IN A REPORT by the United States Public Health Service,1 as well as in one made for the British government,2 it was agreed that BCG production should be carried out by a central laboratory. The reasons for this universal agreement were: (1) to afford a standard method of comparison; (2) to maintain the fastidiousness of the organism; (3) to guarantee the minute care necessary in production of the vaccine, as the final product is a living organism to which no preservative can be added, and (4) to insure accurate and careful determination of the virulence.

If such a program is followed, the results of vaccination in human subjects in various parts of the country can be readily correlated and the stability of the organisms assured.

HISTORIC ASPECTS  A review of the literature reveals that "accidents" have occurred when central laboratories well qualified to produce the vaccine were not